#217 Josh Wolfe: Human Advantage in the World of AI

While Silicon Valley chases unicorns, Josh Wolfe hunts for something far more elusive: scientific breakthroughs that could change civilization. As co-founder and managing partner of Lux Capital, he's looking for the kind of science that turns impossible into inevitable. Josh doesn’t just invest in the future—he sees it coming before almost anyone else.

In this conversation, we explore:

The rapid evolution of AI and potential bottlenecks slowing its growth

The geopolitical battle for technological dominance and rise of sovereign AI models

How advances in automation, robotics, and defence are shifting global power dynamics

Josh's unfiltered thoughts on Tesla and Elon Musk

AI's revolution of medical research

Parenting in a tech-dominated world

How AI is forcing us to rethink creativity, intellectual property, and human intelligence itself

Why the greatest risk isn't AI itself—but our ability to separate truth from noise

Despite the challenges ahead, Josh remains profoundly optimistic about human potential. He believes technology isn't replacing what makes us human—it's amplifying it. This episode will challenge how you think about innovation, risk, and the forces shaping our future. If you want to stay ahead of the curve, you can't afford to miss it.

Josh Wolfe co-founded Lux Capital to support scientists and entrepreneurs who pursue counter-conventional solutions to the most vexing puzzles of our time. He previously worked in investment banking at Salomon Smith Barney and in capital markets at Merrill Lynch. Josh is a columnist with Forbes and Editor for the Forbes/Wolfe Emerging Tech Report.

(00:00:00) Introduction
(00:02:46) Current Obsessions
(00:05:11) AI and its Limitations
(00:10:58) Memory Players in AI
(00:13:27) Human Intelligence as a Limiting Factor
(00:15:38) Disruption in Elite Professions
(00:17:15) AI and Blue-Collar Jobs
(00:18:29) Implications of AI in Coding
(00:19:40) AI and Company Margins
(00:25:48) AI in Pharma
(00:26:44) AI in Entertainment
(00:28:04) AI in Scientific Research
(00:33:31) AI in Patent Creation
(00:34:49) AI in Company Creation
(00:35:33) Discussion on Tesla and Elon Musk
(00:40:54) AI in Investment Decisions
(00:42:20) AI in Analyzing Business Fundamentals
(00:45:27) AI, Privacy, and Information Gods
(00:53:04) AI and Art
(00:56:43) AI and Human Connection
(00:58:22) AI, Aging, and Memory
(01:00:46) The Impact of Remote Work on Social Dynamics
(01:03:18) The Role of Community and Belonging
(01:05:44) The Pursuit of Longevity
(01:11:58) The Importance of Family and Purpose
(01:14:18) Information Processing and Workflow
(01:26:03) Investment in Military Technology
(01:28:09) Global Conflict and Military Deterrence
(01:31:28) Information Warfare
(01:32:32) Infiltration and Weaponization of Systems
(01:37:06) Infrastructure Maintenance and Growth
(01:38:27) DOGE Initiative
(01:40:09) Attracting Capital and Global Competitiveness
(01:43:16) Attracting Talent and Immigration
(01:45:42) Designing a System from Scratch
(01:47:30) AI and Intellectual Property
(01:51:56) The Fear of AI

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